Hypoventilatory respiratory failure in generalised scleroderma
نویسندگان
چکیده
منابع مشابه
Progressive generalized scleroderma: respiratory failure from primary chest wall involvement.
A 73-year-old woman presented with an eight-month history of swelling of the right leg. The calf and ankle were found normal, but there was non-pitting swelling of the thigh of "woody" consistency. Both flanks were firm with cutaneous thickening. There were no other abnormal physical findings. A cutaneous biopsy confirmed the diagnosis of scleroderma. The chest radiograph was normal and initial...
متن کاملThe Pulmonary Manifestations of Generalised Scleroderma
Two aspects of generalised scleroderma have received much attention in recent years. Firstly, the widespread and sclerotic nature of the disease process has been embodied in the term “progressive systemic sclerosis,” proposed by Goetz’ in 1945, and since adopted by other authors. Secondly, connective tissue alterations are now regarded as an integral part of this entity which answers all the cr...
متن کاملEUROPEAN RESPIRATORY UPDATE Scleroderma lung disease
S ystemic sclerosis (SSc) is a systemic autoimmune disease that is characterised by endothelial dysfunction resulting in a small-vessel vasculopathy, fibroblast dysfunction with resultant excessive collagen production and fibrosis, and immunological abnormalities. The classification of SSc is subdivided based on the extent of skin involvement into diffuse cutaneous sclerosis (dcSSc), limited cu...
متن کاملFailure of relaxin inthe treatment of scleroderma.
Relaxin (Hisaw, 1926) is an ovarian polypeptide hormone (Frieden and Hisaw, 1953), which appears in the serum during pregnancy in most mammals, including women (Perkoff, Salhanick, Zarrow, Nelson, and Tyler, 1954). Its action, which is blocked by testosterone or adrenal corticosteroids (Brennan and Zarrow, 1957) and increased by oestrogens (Hall, 1947), is to produce changes in the ground subst...
متن کاملRespiratory function in systemic lupus erythematosus, scleroderma, and rheumatoid arthritis.
Pulmonary involvement is a frequent systemic manifestation of connective tissue diseases. The lesions in lungs are nonspecific, characterized by interstitial fibrosis, bronchiolitis, bronchiolectasis, cystic changes, pleural thickening, and variable degrees of vasculitis (Crofton and Douglas, 1969; Bates, Macklem, and Christie, 1971; Popper, Bogdonoff, and Hughes, 1972). Clinical studies on the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1983
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.286.6362.337